Development of an Effective Whole-Spore Vaccine To Protect against Microsporidial Gill Disease in Rainbow Trout (Oncorhynchus mykiss) by Using a Low-Virulence Strain ofLoma salmonae | Zendy

David J. Speare | Zendy; Robert Markham | Zendy; Nicole Guselle | Zendy

Open Access

Development of an Effective Whole-Spore Vaccine To Protect against Microsporidial Gill Disease in Rainbow Trout (Oncorhynchus mykiss) by Using a Low-Virulence Strain ofLoma salmonae

Author(s) -

David J. Speare,

Robert Markham,

Nicole Guselle

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00365-07

Subject(s) - rainbow trout , gill , virulence , spore , biology , microbiology and biotechnology , strain (injury) , microsporidiosis , adjuvant , trout , fishery , fish <actinopterygii> , virology , zoology , immunology , anatomy , microsporidia , gene , genetics

In determining the effective vaccine spore dose of a low-virulence strain of Loma salmonae to limit microsporidial gill disease in trout, we found that fish receiving 10(3) to 10(5) killed spores had the best protection against experimental infection, with 85% fewer xenomas in their gills than in the controls. Intraperitoneal delivery of the vaccine was effective, and the addition of adjuvant did not improve vaccine performance against this disease-causing microsporidian.

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