Open AccessThe Inverse Correlation between Staphylococcus aureus and Streptococcus pneumoniae Colonization in Infants Is Not Explained by Differences in Serum Antibody Levels in the Generation R Study
Author(s) -
Ankie Lebon,
Nelianne J. Verkaik,
Corné P. de Vogel,
Herbert Hooijkaas,
Henri A. Verbrugh,
Willem J. B. van Wamel,
Vincent W. V. Jaddoe,
Albert Hofman,
Peter W. M. Hermans,
Tim Mitchell,
Henriëtte A. Moll,
Alex van Belkum
Publication year - 2011
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00357-10
Subject(s) - staphylococcus aureus , streptococcus pneumoniae , colonization , microbiology and biotechnology , antibody , biology , medicine , immunology , bacteria , antibiotics , genetics
Colonization rates of Streptococcus pneumoniae and Staphylococcus aureus are inversely correlated in infants. Several studies have searched for determinants of this negative association. We studied the association between antipneumococcal antibodies with Staphylococcus aureus colonization and the association between antistaphylococcal antibodies with pneumococcal colonization in healthy children in the pneumococcal vaccine era. In the first year of life, no association between maternal IgG levels and colonization was seen. In addition, no association between the IgG and IgA levels in the child versus colonization status was seen.