Open AccessLong-Term Observation of Subunit Vaccine F1-rV270 against Y ersinia pestis in Mice
Author(s) -
Zuyun Wang,
Lei Zhou,
Qi Zhang,
Qingwen Zhang,
Ruixia Dai,
Yong Yang,
Baizhong Cui,
Hu Wang,
Ruifu Yang,
Xiaoyi Wang
Publication year - 2010
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00305-09
Subject(s) - yersinia pestis , immunization , virology , protein subunit , antibody , biology , term (time) , plague (disease) , microbiology and biotechnology , immunology , medicine , virulence , genetics , physics , quantum mechanics , gene , pathology
Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge ofYersinia pestis could be achieved up to day 518 after primary immunization.