Hepatitis B Virus Antibody Levels 7 to 9 Years after Booster Vaccination in Alaska Native Persons | Zendy

James W. Keck | Zendy; Lisa Bulkow | Zendy; Gregory Raczniak | Zendy; Susan Negus | Zendy; Carolyn Zanis | Zendy; Michael G. Bruce | Zendy; Philip R. Spradling | Zendy; Eyasu H. Teshale | Zendy; Brian J. McMahon | Zendy

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Hepatitis B Virus Antibody Levels 7 to 9 Years after Booster Vaccination in Alaska Native Persons

Author(s) -

James W. Keck,

Lisa Bulkow,

Gregory Raczniak,

Susan Negus,

Carolyn Zanis,

Michael G. Bruce,

Philip R. Spradling,

Eyasu H. Teshale,

Brian J. McMahon

Publication year - 2014

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00263-14

Subject(s) - booster (rocketry) , booster dose , vaccination , medicine , antibody , hepatitis a vaccine , hepatitis b , hepatitis b virus , immunity , immunology , virology , hepatitis b vaccine , hepatitis a , hepatitis , immunization , virus , immune system , hbsag , physics , astronomy

Hepatitis B antibody persistence was assessed in individuals who had previously received a vaccine booster. We measured hepatitis B surface antigen antibody (anti-HBs) levels 7 to 9 years post-hepatitis B booster in individuals with primary vaccination at birth. While 95 (91.3%) of 104 participants had detectable anti-HBs (minimum, 0.1 mIU/ml; maximum, 1,029 mIU/ml), only 43 (41%) had protective levels of ≥10 mIU/ml. Pre- and week 4 postbooster anti-HBs levels were significant predictors of hepatitis B immunity at follow-up (P < 0.001). Almost all participants had detectable anti-HBs 7 to 9 years after the hepatitis B vaccine booster, but less than half had levels ≥10 mIU/ml.

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