Porcine Reproductive and Respiratory Syndrome Virus Infects Mature Porcine Dendritic Cells and Up-Regulates Interleukin-10 Production | Zendy

Lilián Flores-Mendoza | Zendy; Erika SilvaCampa | Zendy; Mónica Reséndiz | Zendy; Fernando A. Osorio | Zendy; Jesús Hernández | Zendy

Open Access

Porcine Reproductive and Respiratory Syndrome Virus Infects Mature Porcine Dendritic Cells and Up-Regulates Interleukin-10 Production

Author(s) -

Lilián Flores-Mendoza,

Erika SilvaCampa,

Mónica Reséndiz,

Fernando A. Osorio,

Jesús Hernández

Publication year - 2008

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00224-07

Subject(s) - cd80 , porcine reproductive and respiratory syndrome virus , biology , virus , major histocompatibility complex , lipopolysaccharide , immunology , respiratory system , interleukin , virology , microbiology and biotechnology , immune system , cytokine , cd40 , cytotoxic t cell , in vitro , genetics , anatomy

Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research