Limited Diagnostic Capacities of Two Commercial Assays for the Detection of Leptospira Immunoglobulin M Antibodies in Laos | Zendy

Stuart D. Blacksell | Zendy; Lee D. Smythe | Zendy; Rattanaphone Phetsouvanh | Zendy; Michael Dohnt | Zendy; Rudy A. Hartskeerl | Zendy; Meegan L. Symonds | Zendy; Andrew Slack | Zendy; Manivanh Vongsouvath | Zendy; Viengmone Davong | Zendy; Olay Lattana | Zendy; Simmaly Phongmany | Zendy; Valy Keolouangkot | Zendy; Nicholas J. White | Zendy; Nicholas Day | Zendy; Paul N. Newton | Zendy

Open Access

Limited Diagnostic Capacities of Two Commercial Assays for the Detection of Leptospira Immunoglobulin M Antibodies in Laos

Author(s) -

Stuart D. Blacksell,

Lee D. Smythe,

Rattanaphone Phetsouvanh,

Michael Dohnt,

Rudy A. Hartskeerl,

Meegan L. Symonds,

Andrew Slack,

Manivanh Vongsouvath,

Viengmone Davong,

Olay Lattana,

Simmaly Phongmany,

Valy Keolouangkot,

Nicholas J. White,

Nicholas Day,

Paul N. Newton

Publication year - 2006

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00219-06

Subject(s) - leptospira , antibody , gold standard (test) , direct agglutination test , leptospirosis , immunoglobulin m , immunoglobulin g , agglutination (biology) , diagnostic test , medicine , virology , immunology , serology , veterinary medicine

The diagnostic utility of immunochromatographic (Leptotek) and enzyme-linked immunosorbent assay (ELISA; Panbio) tests for the detection of Leptospira immunoglobulin M antibodies was assessed in febrile adults admitted in Vientiane, Laos. Both tests demonstrated poor diagnostic accuracy using admission serum (Leptotek sensitivity of 47.3% and specificity of 75.5%: ELISA sensitivity of 60.9% and specificity of 65.6%) compared to the Leptospira "gold standard" microscopic agglutination test.

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