Influence of Common and Specific HLA-DRB1/DQB1 Haplotypes on Genetic Susceptibilities of Three Distinct Arab Populations to Type 1 Diabetes | Zendy

Mouna Stayoussef | Zendy; Jihen Benmansour | Zendy; Fayza A. Al-Jenaidi | Zendy; Rita Nemr | Zendy; Muhallab E. Ali | Zendy; Touhami Mahjoub | Zendy; Wassim Y. Almawi | Zendy

Open Access

Influence of Common and Specific HLA-DRB1/DQB1 Haplotypes on Genetic Susceptibilities of Three Distinct Arab Populations to Type 1 Diabetes

Author(s) -

Mouna Stayoussef,

Jihen Benmansour,

Fayza A. Al-Jenaidi,

Rita Nemr,

Muhallab E. Ali,

Touhami Mahjoub,

Wassim Y. Almawi

Publication year - 2008

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00215-08

Subject(s) - haplotype , locus (genetics) , human leukocyte antigen , genetics , type 1 diabetes , biology , hla dqb1 , allele , gene , diabetes mellitus , antigen , endocrinology

The contribution of HLA DRB-DQB to type 1 diabetes (T1D) in Bahrainis, Lebanese, and Tunisians was investigated. DRB1*030101-DQB1*0201 was a locus that conferred susceptibility in three populations, while DRB1*040101-DQB1*0302 was a locus that conferred susceptibility only in Tunisians and Bahrainis. The DRB1*100101-DQB1*050101 (Bahrainis) and DRB1*150101-DQB1*060101 (Lebanese) loci were largely protective. The contribution of HLA to T1D must be evaluated with regard to ethnic background.

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