Improved Efficacy of a Licensed Acellular Pertussis Vaccine, Reformulated in an Adjuvant Emulsion of Liposomes in Oil, in a Murine Model | Zendy

Marc Mansour | Zendy; Robert G. Brown | Zendy; Annette Morris | Zendy; Bruce R. Smith | Zendy; Scott A. Halperin | Zendy

Open Access

Improved Efficacy of a Licensed Acellular Pertussis Vaccine, Reformulated in an Adjuvant Emulsion of Liposomes in Oil, in a Murine Model

Author(s) -

Marc Mansour,

Robert G. Brown,

Annette Morris,

Bruce R. Smith,

Scott A. Halperin

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00143-07

Subject(s) - adjuvant , bordetella pertussis , emulsion , tetanus , medicine , diphtheria , vaccination , pertussis vaccine , virology , liposome , immunization , diphtheria toxin , whooping cough , microbiology and biotechnology , immunology , antibody , chemistry , biology , toxin , biochemistry , genetics , bacteria

The immunogenicities and efficacies of a licensed diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine and the same vaccine formulated in a liposome/oil emulsion adjuvant were compared in a mouse model of pertussis respiratory infection. A single dose of the liposome/oil emulsion-adjuvanted vaccine produced significantly higher antibody levels than one dose of the licensed vaccine and protected mice from Bordetella pertussis infection with an efficacy equivalent to that of three doses of the licensed vaccine.

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