Open AccessRandomized Clinical Trial To Evaluate the Immunogenicity of Quadrivalent Meningococcal Conjugate and Polysaccharide Vaccines in Adults in the United Kingdom
Author(s) -
Maheshi Ramasamy,
Elizabeth Clutterbuck,
Kathryn Haworth,
Jaclyn Bowman,
Omar Omar,
Amber Thompson,
Géraldine BlanchardRohner,
LyMee Yu,
Matthew D. Snape,
Andrew J. Pollard
Publication year - 2014
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00099-14
Subject(s) - immunogenicity , meningococcal meningitis , meningococcal vaccine , conjugate , medicine , randomized controlled trial , meningitis , conjugate vaccine , clinical trial , neisseria meningitidis , immunology , antibody , pediatrics , immunization , biology , mathematical analysis , mathematics , genetics , bacteria
Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).
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