Open AccessDevelopment and Characterization of an Equine Infectious Anemia Virus Env-Pseudotyped Reporter Virus
Author(s) -
Rebecca L. Tallmadge,
Melinda A. Brindley,
J. Salmans,
Robert H. Mealey,
Wendy Maury,
Susan Carpenter
Publication year - 2008
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00088-08
Subject(s) - equine infectious anemia , virology , virus , lentivirus , biology , viral replication , glycoprotein , neutralization , viral disease , genetics
We developed a replication-defective reporter virus pseudotyped with the envelope glycoprotein of equine infectious anemia virus (EIAV). The in vitro host range and neutralization phenotype of EIAV Env-pseudotyped virus were similar to those of replication-competent virus. An EIAV Env pseudovirus will improve antigenic characterization of viral variants and evaluation of lentivirus vaccines.
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