Open AccessEnhancement of Diagnostic Efficiency by a Gamma Interferon Release Assay for Pulmonary Tuberculosis
Author(s) -
Kelly Aparecida Kanunfre,
Olavo Henrique Munhoz Leite,
Max Igor Banks Ferreira Lopes,
Marcelo Nóbrega Litvoc,
Antônio Walter Ferreira
Publication year - 2008
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00026-08
Subject(s) - pulmonary tuberculosis , tuberculosis , interferon gamma release assay , interferon gamma , medicine , mycobacterium tuberculosis , virology , immunology , pathology , latent tuberculosis , cytokine
This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >or=0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test.
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