Activated T Lymphocytes Disappear from Circulation during Endotoxemia in Humans | Zendy

K. S. Krabbe | Zendy; Helle Brüünsgaard | Zendy; J Qvist | Zendy; Lise Fonsmark | Zendy; Kirsten Møller | Zendy; Christian M. Hansen | Zendy; Peter Skinhøj | Zendy; Bente Klarlund Pedersen | Zendy

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Activated T Lymphocytes Disappear from Circulation during Endotoxemia in Humans

Author(s) -

K. S. Krabbe,

Helle Brüünsgaard,

J Qvist,

Lise Fonsmark,

Kirsten Møller,

Christian M. Hansen,

Peter Skinhøj,

Bente Klarlund Pedersen

Publication year - 2002

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cdli.9.3.731-735.2002

Subject(s) - apoptosis , phenotype , cd28 , fas receptor , immunology , biology , medicine , immune system , endocrinology , microbiology and biotechnology , programmed cell death , t cell , gene , genetics

Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

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