Human Dengue Antibodies against Structural and Nonstructural Proteins | Zendy

Katia Valdés | Zendy; Mayling Álvarez | Zendy; Maritza Pupo | Zendy; Susana Vázquez | Zendy; Rayner Rodrı́guez | Zendy; María G. Guzmán | Zendy

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Human Dengue Antibodies against Structural and Nonstructural Proteins

Author(s) -

Katia Valdés,

Mayling Álvarez,

Maritza Pupo,

Susana Vázquez,

Rayner Rodrı́guez,

María G. Guzmán

Publication year - 2000

Publication title -

clinical and diagnostic laboratory immunology

Language(s) - English

Resource type - Journals

eISSN - 1098-6588

pISSN - 1071-412X

DOI - 10.1128/cdli.7.5.856-857.2000

Subject(s) - dengue fever , ns3 , antibody , dengue virus , virology , structural protein , blot , immune system , antigen , biology , immunology , virus , biochemistry , hepatitis c virus , gene

Antibodies against dengue virus type 2 and 4 proteins in acute-phase sera of 10 primary and 10 secondary dengue fever and dengue hemorrhagic fever patients were studied by Western blotting. In the first group the immune response was barely detectable, while in the second group more proteins were detected, with a very strong reaction. Anti-NS1 and -NS3 antibodies were detected mainly in secondary cases. Anti-E, -NS3, and -NS5 antibodies were detected in a high number of cases. The possibility of implementing early diagnostic assays for antigen detection is suggested.

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