Open AccessHighly Active Antiretroviral Therapy (HAART) and Circulating Markers of Immune Activation: Specific Effect of HAART on Neopterin
Author(s) -
Nathalie Amirayan-Chevillard,
Hervé TissotDupont,
Yolande Obadia,
H Gallais,
JeanLouis Mège,
Christian Capo
Publication year - 2000
Publication title -
clinical and diagnostic laboratory immunology
Language(s) - English
Resource type - Journals
eISSN - 1098-6588
pISSN - 1071-412X
DOI - 10.1128/cdli.7.5.832-834.2000
Subject(s) - neopterin , immunology , immune system , tumor necrosis factor alpha , antiretroviral therapy , medicine , human immunodeficiency virus (hiv) , immunopathology , viral load
The circulating levels of immune activation markers, including neopterin, tumor necrosis factor receptor type II, and interleukin-2 receptors, are increased in human immunodeficiency virus-infected patients. We show here that highly active antiretroviral therapy significantly decreased neopterin levels. This effect is reversible, since neopterin levels increased after the arrest of treatment. Their determination may be useful in the evaluation of the efficacy of antiretroviral therapy.