Streptococcal DNase B Is Immunologically Identical to Superantigen SpeF but Involves Separate Domains | Zendy

Anna Eriksson | Zendy; Björn Eriksson | Zendy; Stig E. Holm | Zendy; Mari Norgren | Zendy

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Streptococcal DNase B Is Immunologically Identical to Superantigen SpeF but Involves Separate Domains

Author(s) -

Anna Eriksson,

Björn Eriksson,

Stig E. Holm,

Mari Norgren

Publication year - 1999

Publication title -

clinical and diagnostic laboratory immunology

Language(s) - English

Resource type - Journals

eISSN - 1098-6588

pISSN - 1071-412X

DOI - 10.1128/cdli.6.1.133-136.1999

Subject(s) - superantigen , polyclonal antibodies , nuclease , deoxyribonuclease i , epitope , biology , streptococcus pyogenes , microbiology and biotechnology , antiserum , antigen , dna , immune system , t cell , bacteria , immunology , base sequence , genetics , staphylococcus aureus

The previous suggestion that streptococcal superantigen SpeF might be identical to DNase B was confirmed in this study. Polyclonal SpeF-specific antisera were able to inhibit depolymerization of methyl-green DNA by DNase B. However, T-cell mitogenicity and nuclease activity appear to involve separate immune epitopes on SpeF, since sera with the capacity to neutralize the mitogenic activity of SpeF did not always inhibit the DNase activity.

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