Open AccessUse of the COOH Portion of the Nucleocapsid Protein in an Antigen-Capturing Enzyme-Linked Immunosorbent Assay for Specific and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus
Author(s) -
Maofeng Qiu,
Jin Wang,
Hongxia Wang,
Zeliang Chen,
Erhei Dai,
Zhaobiao Guo,
Xiaoyi Wang,
Xin Pang,
Baoxing Fan,
Jie Wen,
Jian Wang,
Ruifu Yang
Publication year - 2005
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.12.3.474-476.2005
Subject(s) - covid-19 , antigen , coronavirus , virology , enzyme , medicine , betacoronavirus , respiratory system , immunology , chemistry , biochemistry , pathology , outbreak , disease , infectious disease (medical specialty)
Antibody detection with a recombinant COOH portion of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid (N) protein, N13 (amino acids 221 to 422), was demonstrated to be more specific and sensitive than that with the full-length N protein, and an N13-based antigen-capturing enzyme-linked immunosorbent assay providing a convenient and specific test for serodiagnosis and epidemiological study of SARS was developed.
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