Antifungal Activity of Ring Poly-Chlorinated Pyrimidines: Structure Activity Relationships | Zendy

Herman Gershon | Zendy; Raulo Parmegiani | Zendy

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Antifungal Activity of Ring Poly-Chlorinated Pyrimidines: Structure Activity Relationships

Author(s) -

Herman Gershon,

Raulo Parmegiani

Publication year - 1963

Publication title -

applied microbiology

Language(s) - English

Resource type - Journals

ISSN - 0003-6919

DOI - 10.1128/am.11.2.78-83.1963

Subject(s) - antifungal , ring (chemistry) , chemistry , stereochemistry , structure–activity relationship , liquid culture , medicinal chemistry , organic chemistry , microbiology and biotechnology , biology , biochemistry , botany , in vitro

A total of 48 ring chlorinated pyrimidines was screened against strains of five fungi by the disc-plate method, in liquid culture, and for activity of the vapors of the compounds. Correlations of the results obtained by the three methods were made, and structure to activity relationships were discussed. The outstanding members of this series were found to be 2,4,5-trichloropyrimidine, 4,5,6-trichloropyrimidine, and 2-chloromethyl-4,5,6-trichloropyrimidine, in this screening system.

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