Open AccessThe Bifidobacterium longum NCIMB 702259 T ctr Gene Codes for a Novel Cholate Transporter
Author(s) -
Claire E. Price,
Sharon J. Reid,
Arnold J. M. Driessen,
Valerie R. Abratt
Publication year - 2006
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.72.1.923-926.2006
Subject(s) - efflux , bifidobacterium longum , atp binding cassette transporter , escherichia coli , biology , transporter , mutant , chloramphenicol , microbiology and biotechnology , bifidobacterium , biochemistry , chemistry , gene , antibiotics , fermentation , lactobacillus
Preexposure of Bifidobacterium longum NCIMB 702259T to cholate caused increased resistance to cholate, chloramphenicol, and erythromycin. The B. longum ctr gene, encoding a cholate efflux transporter, was transformed into the efflux-negative mutant Escherichia coli KAM3, conferring resistance to bile salts and other antimicrobial compounds and causing the efflux of [14C]cholate.
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