Open AccessRapid Detection of Subtype-Selective Nuclear Hormone Receptor Binding with Bacterial Genetic Selection
Author(s) -
Γεώργιος Σκρέτας,
David Wood
Publication year - 2005
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.71.12.8995-8997.2005
Subject(s) - nuclear receptor , escherichia coli , biology , hormone receptor , receptor , hormone , computational biology , biochemistry , gene , genetics , transcription factor , cancer , breast cancer
Subtype-selective nuclear hormone receptor modulators could potentially allow the development of valuable tissue-specific therapeutics. A simple biosensor that allows subtype-specific nuclear hormone receptor binding to be reflected by the growth phenotype ofEscherichia coli cells has been constructed. This system will potentially enable the facile detection or evolution of subtype-selective hormone analogues.