Effect of biotin on alkaloid production during submerged cultivation of Claviceps sp. strain SD-58 | Zendy

J. D. Desai | Zendy; Anjana J. Desai | Zendy; H. Patel | Zendy

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Effect of biotin on alkaloid production during submerged cultivation of Claviceps sp. strain SD-58

Author(s) -

J. D. Desai,

Anjana J. Desai,

H. Patel

Publication year - 1983

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.45.5.1694-1696.1983

Subject(s) - alkaloid , biotin , chlamydospore , claviceps purpurea , biotin deficiency , strain (injury) , yield (engineering) , biology , food science , botany , biochemistry , chemistry , spore , materials science , anatomy , metallurgy

Addition of biotin to culture medium NL-406 significantly increased alkaloid yield during submerged cultivation of Claviceps sp. strain SD-58. Alkaloid yield was further enhanced by incorporating leucine in biotin-supplemented culture medium. Increased alkaloid production was associated with an increase in the lipid content of cells and in the number of chlamydospores. Biotin deficiency caused a reduction in alkaloid yield and a parallel decrease in lipid content and chlamydospore numbers.

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