Open AccessTransformation of Adenine to 8-Hydroxyadenine by Strains of Oerskovia xanthineolytica
Author(s) -
Mary P. Lechevalier,
Nancy N. Gerber,
Thomas A. Umbreit
Publication year - 1982
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.43.2.367-370.1982
Subject(s) - hypoxanthine , xanthine , purine , uric acid , transformation (genetics) , biochemistry , purine metabolism , chemistry , microbiology and biotechnology , biology , enzyme , gene
The 8-hydroxy derivative of adenine (6-amino-1,7-dihydro-8H -purin-8-one) is produced from adenine by twoOerskovia xanthineolytica strains. This transformation by a microorganism has not been reported previously. No novel products of dissimilation of xanthine (3,7-dihydro-1H -purine-2,6-dione) or hypoxanthine (1,7-dihydro-6H -purin-6-one) were found. Xanthine was oxidized to uric acid, but intermediates in the breakdown of hypoxanthine could not be demonstrated.
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