Leptospire Genomic Diversity Revealed by Microarray-Based Comparative Genomic Hybridization | Zendy

Broderick E. Eribo | Zendy; Sirima Mingmongkolchai | Zendy; Tingfen Yan | Zendy; Padunsri Dubbs | Zendy; William Nelson | Zendy

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Leptospire Genomic Diversity Revealed by Microarray-Based Comparative Genomic Hybridization

Author(s) -

Broderick E. Eribo,

Sirima Mingmongkolchai,

Tingfen Yan,

Padunsri Dubbs,

William Nelson

Publication year - 2012

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.07465-11

Subject(s) - leptospira interrogans , serotype , biology , leptospira , virulence , genome , genetic diversity , comparative genomic hybridization , microbiology and biotechnology , genetics , gene , population , medicine , environmental health

Comparative genomic hybridization was used to compare genetic diversity of five strains of Leptospira (Leptospira interrogans serovars Bratislava, Canicola, and Hebdomadis and Leptospira kirschneri serovars Cynopteri and Grippotyphosa). The array was designed based on two available sequenced Leptospira reference genomes, those of L. interrogans serovar Copenhageni and L. interrogans serovar Lai. A comparison of genetic contents showed that L. interrogans serovar Bratislava was closest to the reference genomes while L. kirschneri serovar Grippotyphosa had the least similarity to the reference genomes. Cluster analysis indicated that L. interrogans serovars Bratislava and Hebdomadis clustered together first, followed by L. interrogans serovar Canicola, before the two L. kirschneri strains. Confirmed/potential virulence factors identified in previous research were also detected in the tested strains.

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