Role of (p)ppGpp in Biofilm Formation by Enterococcus faecalis | Zendy

Luis E. Chávez de Paz | Zendy; José A. Lemos | Zendy; Claes Wickström | Zendy; Christine Sedgley | Zendy

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Role of (p)ppGpp in Biofilm Formation by Enterococcus faecalis

Author(s) -

Luis E. Chávez de Paz,

José A. Lemos,

Claes Wickström,

Christine Sedgley

Publication year - 2011

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.07036-11

Subject(s) - biofilm , enterococcus faecalis , microbiology and biotechnology , mutant , strain (injury) , biology , enterococcus , streptococcaceae , bacteria , chemistry , escherichia coli , biochemistry , antibiotics , gene , genetics , anatomy

Enterococcus faecalis strain OG1RF and its (p)ppGpp-deficient ΔrelA, ΔrelQ, and ΔrelA ΔrelQ mutants were grown in biofilms and evaluated for growth profiles, biofilm morphology, cell viability, and proteolytic activity. E. faecalis lacking (p)ppGpp had a diminished capacity to sustain biofilm formation over an extended period of time and expressed abundant proteolytic activity.

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