Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus | Zendy

Ashley N. Brown | Zendy; Kathryn Smith | Zendy; Tova A. Samuels | Zendy; Jiangrui Lu | Zendy; Sherine O. Obare | Zendy; Maria E. Scott | Zendy

Open Access

Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus

Author(s) -

Ashley N. Brown,

Kathryn Smith,

Tova A. Samuels,

Jiangrui Lu,

Sherine O. Obare,

Maria E. Scott

Publication year - 2012

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.06513-11

Subject(s) - enterobacter aerogenes , pseudomonas aeruginosa , microbiology and biotechnology , staphylococcus aureus , ampicillin , antibiotics , enterobacter , amp resistance , biology , chemistry , bacteria , escherichia coli , biochemistry , genetics , gene

We show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.

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