Insights into the Function of the N -Acetyltransferase SatA That Detoxifies Streptothricin in Bacillus subtilis and Bacillus anthracis | Zendy

Rachel M. Burckhardt | Zendy; Jorge C. EscalanteSemerena | Zendy

Open Access

Insights into the Function of the N -Acetyltransferase SatA That Detoxifies Streptothricin in Bacillus subtilis and Bacillus anthracis

Author(s) -

Rachel M. Burckhardt,

Jorge C. EscalanteSemerena

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.03029-18

Subject(s) - bacillus subtilis , bacillus anthracis , acetyltransferase , function (biology) , bacillus (shape) , microbiology and biotechnology , biology , chemistry , bacteria , biochemistry , acetylation , genetics , gene

This work provides insights into how an abundant antibiotic found in soil is bound to the enzyme that inactivates it. This work identifies residues for the binding of the antibiotic and probes the contributions of substituting side chains for those in the native protein, providing information regarding hydrophobicity, size, and flexibility of the antibiotic binding site.

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