Cg Hog1-Mediated Cg Rds2 Phosphorylation Alters Glycerophospholipid Composition To Coordinate Osmotic Stress in Candida glabrata
Author(s) -
Chengjin Wu,
Jiali Zhang,
Guoxing Zhu,
Rui Yao,
Xiulai Chen,
Li Liu
Publication year - 2019
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.02822-18
Subject(s) - glycerophospholipid , phosphorylation , osmotic shock , biology , wild type , microbiology and biotechnology , biochemistry , transcription factor , cell growth , chemistry , gene , membrane , mutant , phospholipid
This study explored the role ofCg Hog1-mediatedCg Rds2 phosphorylation in response to osmotic stress inCandida glabrata .Cg Hog1 interacts with and phosphorylatesCg Rds2, a zinc cluster transcription factor, under osmotic stress. PhosphorylatedCg Rds2 plays an important role in increasing glycerophospholipid composition and membrane integrity, thereby enhancing cell growth and survival.
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