Molecular and Functional Analysis of the Type IV Pilus Gene Cluster in Streptococcus sanguinis SK36 | Zendy

YiYwan M. Chen | Zendy; YiChien Chiang | Zendy; Tzu-Ying Tseng | Zendy; Hui-Yu Wu | Zendy; Yueh-Ying Chen | Zendy; Chia-Hua Wu | Zendy; ChengHsun Chiu | Zendy

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Molecular and Functional Analysis of the Type IV Pilus Gene Cluster in Streptococcus sanguinis SK36

Author(s) -

YiYwan M. Chen,

YiChien Chiang,

Tzu-Ying Tseng,

Hui-Yu Wu,

Yueh-Ying Chen,

Chia-Hua Wu,

ChengHsun Chiu

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.02788-18

Subject(s) - gene cluster , operon , biology , streptococcus sanguinis , pilus , pilin , promoter , genetics , gene , microbiology and biotechnology , gene expression , biofilm , bacteria , escherichia coli

The proteins and assembly machinery of the type IV pili (Tfp) are conserved throughout bacteria and archaea, and yet the function of this surface structure differs from species to species and even from strain to strain. As seen inStreptococcus sanguinis SK36, the expression of the Tfp gene cluster results in a hairlike surface structure that is much shorter than the typical Tfp. This pilus is essential for the adherence of SK36 but is not involved in motility. Being a member of the highly diverse dental biofilm, perhapsS. sanguinis could more effectively utilize this structure to adhere to host cells and to interact with other microbes within the same niche.

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