Unusual Codon Bias in Vinyl Chloride Reductase Genes of Dehalococcoides Species | Zendy

Paul J. McMurdie | Zendy; Sebastian Behrens | Zendy; Susan Holmes | Zendy; Alfred M. Spormann | Zendy

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Unusual Codon Bias in Vinyl Chloride Reductase Genes of Dehalococcoides Species

Author(s) -

Paul J. McMurdie,

Sebastian Behrens,

Susan Holmes,

Alfred M. Spormann

Publication year - 2007

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.02768-06

Subject(s) - dehalococcoides , vinyl chloride , codon usage bias , gene , genetics , biology , computational biology , genome , chemistry , organic chemistry , copolymer , polymer

Vinyl chloride reductases (VC-RDase) are the key enzymes for complete microbial reductive dehalogenation of chloroethenes, including the groundwater pollutants tetrachloroethene and trichloroethene. Analysis of the codon usage of the VC-RDase genes vcrA and bvcA showed that these genes are highly unusual and are characterized by a low G+C fraction at the third position. The third position of codons in VC-RDase genes is biased toward the nucleotide T, even though available Dehalococcoides genome sequences indicate the absence of any tRNAs matching codons that end in T. The comparatively high level of abnormality in the codon usage of VC-RDase genes suggests an evolutionary history that is different from that of most other Dehalococcoides genes.

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