An Extracytoplasmic Function Sigma Factor Controls Cellulose Utilization by Regulating the Expression of an Outer Membrane Protein in Cytophaga hutchinsonii | Zendy

Xia Wang | Zendy; Weixin Zhang | Zendy; Hong Zhou | Zendy; Guanjun Chen | Zendy; Weifeng Liu | Zendy

Open Access

An Extracytoplasmic Function Sigma Factor Controls Cellulose Utilization by Regulating the Expression of an Outer Membrane Protein in Cytophaga hutchinsonii

Author(s) -

Xia Wang,

Weixin Zhang,

Hong Zhou,

Guanjun Chen,

Weifeng Liu

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.02606-18

Subject(s) - cellulose , bacterial outer membrane , gene , mutant , biochemistry , bacteria , cytophaga , biology , microbiology and biotechnology , chemistry , gene expression , polysaccharide , escherichia coli , genetics , pseudomonas , flavobacterium

The common cellulolytic bacteriumCytophaga hutchinsonii uses a unique but poorly understood strategy in order to make use of cellulose. Throughout the process of cellulosic biomass breakdown, outer membrane proteins are thought to play key roles; this is evidenced by CHU_1276, which is required for the utilization of cellulose. However, the regulatory mechanism of its expression is not yet known. We found and characterized an extracytoplasmic function σ factor that is involved in coordinating the cellulolytic response ofC. hutchinsonii by directly regulating the expression ofCHU_1276 . This study makes a contribution to our understanding of the regulatory mechanism used byC. hut chinsonii in order to adjust its genetic programs and so deal with novel environmental cues.

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