Reduction of Acid Tolerance by Tetracycline in Escherichia coli Expressing tetA (C) Is Reversed by Cations | Zendy

Kai F. Hung | Zendy; Jeffrey J. Byrd | Zendy; Jeffrey L. Bose | Zendy; Charles W. Kaspar | Zendy

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Reduction of Acid Tolerance by Tetracycline in Escherichia coli Expressing tetA (C) Is Reversed by Cations

Author(s) -

Kai F. Hung,

Jeffrey J. Byrd,

Jeffrey L. Bose,

Charles W. Kaspar

Publication year - 2006

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.02519-05

Subject(s) - escherichia coli , rpos , magnesium , tetracycline , chemistry , sodium , potassium , calcium , sucrose , biochemistry , antibiotics , gene expression , gene , organic chemistry , promoter

When tetracycline was present,tetA (C) reduced acid tolerance, suppressedrpoS expression, and increased the concentration of total soluble proteins in stationary-phaseEscherichia coli . The suppression of acid tolerance was reversed by 85 mM sodium, potassium, magnesium, and calcium ions but not by 85 mM sucrose. Implications for using TetA(C) are discussed.

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