Differential Effects of Breed and Nursing on Early-Life Colonic Microbiota and Immune Status as Revealed in a Cross-Fostering Piglet Model | Zendy

Chunlong Mu | Zendy; Gaorui Bian | Zendy; Yong Su | Zendy; Weiyun Zhu | Zendy

Open Access

Differential Effects of Breed and Nursing on Early-Life Colonic Microbiota and Immune Status as Revealed in a Cross-Fostering Piglet Model

Author(s) -

Chunlong Mu,

Gaorui Bian,

Yong Su,

Weiyun Zhu

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.02510-18

Subject(s) - breed , immune system , biology , gut flora , immune status , immunity , gompertz function , cytokine , immunology , physiology , zoology , machine learning , computer science

Early-life gut microbiota and immune status are pivotal for postnatal growth. By using an interspecific cross-fostering piglet model, we find that change in nursing mother transiently reshapes preweaning colon microbiota and immune status, while breed shows persistent effects both pre- and postweaning. Piglets nursed by Meishan sows had lowerStreptococcus suis counts and higher anti-inflammatory cytokine expression. These results highlight the significance of nursing mother in regulating early-life gut health.

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