Open AccessMolecular Diversification in the Quorum-Sensing System of Vibrio cholerae : Role of Natural Selection in the Emergence of Pandemic Strains
Author(s) -
Nina M. Talyzina,
Pär K. Ingvarsson,
Jun Zhu,
Sun Nyunt Wai,
Agneta Andersson
Publication year - 2009
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.02496-08
Subject(s) - vibrio cholerae , cholera , pandemic , biology , quorum sensing , microbiology and biotechnology , virology , virulence , genetics , gene , covid-19 , bacteria , medicine , infectious disease (medical specialty) , disease , pathology
Two haplotypes of theVibrio cholerae quorum-sensing system regulatorhapR are described:hapR1 , common among nonpandemic, non-O1, non-O139 strains, andhapR2 , associated with pandemic O1 and O139 and epidemic O37V. cholerae strains. ThehapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.