Steryl Ester Formation and Accumulation in Steroid-Degrading Bacteria | Zendy

Johannes Holert | Zendy; Kirstin Brown | Zendy; Ameena Hashimi | Zendy; Lindsay D. Eltis | Zendy; William W. Mohn | Zendy

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Steryl Ester Formation and Accumulation in Steroid-Degrading Bacteria

Author(s) -

Johannes Holert,

Kirstin Brown,

Ameena Hashimi,

Lindsay D. Eltis,

William W. Mohn

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.02353-19

Subject(s) - bacteria , sterol , food science , chemistry , nutraceutical , cholesterol , steroid , biochemistry , fatty acid , biology , genetics , hormone

Oleaginous bacteria exhibit great potential for the production of high-value neutral lipids, such as triacylglycerols and wax esters. This study describes the formation of steryl esters (SEs) as neutral lipid storage compounds in sterol-degrading oleaginous bacteria, providing a basis for biotechnological production of SEs using bacterial systems with potential applications in the functional food, nutraceutical, and cosmetic industries. We found cholesteryl ester (CE) formation in several sterol-degradingActino - andProteobacteria under nitrogen-limiting conditions, suggesting an important role of this process in storing energy and carbon under adverse conditions. In addition,Mycobacterium tuberculosis grown on cholesterol accumulated CEs in the presence of an additional fatty acid substrate.

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