Open AccessEnterocin X, a Novel Two-Peptide Bacteriocin from Enterococcus faecium KU-B5, Has an Antibacterial Spectrum Entirely Different from Those of Its Component Peptides
Author(s) -
Chih Bo Hu,
Wanna Malaphan,
Takeshi Zendo,
Jiro Nakayama,
Kenji Sonomoto
Publication year - 2010
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.02264-09
Subject(s) - bacteriocin , enterococcus faecium , peptide , antibacterial peptide , antibacterial activity , microbiology and biotechnology , biology , antibacterial agent , bacteria , biochemistry , antimicrobial , antibiotics , genetics
Enterocin X, composed of two antibacterial peptides (Xα and Xβ), is a novel class IIb bacteriocin fromEnterococcus faecium KU-B5. When combined, Xα and Xβ display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. InE. faecium strains that produce enterocins A and B, such as KU-B5, only one additional bacteriocin had previously been known.