Isolation of a Novel Aggregatibacter actinomycetemcomitans Serotype b Bacteriophage Capable of Lysing Bacteria within a Biofilm | Zendy

Mario CastilloRuiz | Zendy; Enrique D. Vinés | Zendy; Camilo Montt | Zendy; Jorge Onrubia Fernández | Zendy; José Manuel Delgado | Zendy; Juan Carlos Hormazábal | Zendy; Mauricio Bittner | Zendy

Open Access

Isolation of a Novel Aggregatibacter actinomycetemcomitans Serotype b Bacteriophage Capable of Lysing Bacteria within a Biofilm

Author(s) -

Mario CastilloRuiz,

Enrique D. Vinés,

Camilo Montt,

Jorge Onrubia Fernández,

José Manuel Delgado,

Juan Carlos Hormazábal,

Mauricio Bittner

Publication year - 2011

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.02115-10

Subject(s) - microbiology and biotechnology , bacteriophage , aggregatibacter actinomycetemcomitans , bacteria , biofilm , biology , serotype , isolation (microbiology) , lysis , virology , escherichia coli , gene , genetics , porphyromonas gingivalis

A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. Random mutagenesis of this phage rendered a bacteriophage able to kill 99% of the bacteria within a biofilm. This is the first report of a biocontrol experiment against A. actinomycetemcomitans.

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