Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C -Nucleoside Scaffolds | Zendy

Meng Zhang | Zendy; Peichao Zhang | Zendy; Gudan Xu | Zendy; Wenting Zhou | Zendy; Yaojie Gao | Zendy; Rong Gong | Zendy; YouSheng Cai | Zendy; Hengjiang Cong | Zendy; Zixin Deng | Zendy; Neil P. J. Price | Zendy; Xiangzhao Mao | Zendy; Wenqing Chen | Zendy

Open Access

Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C -Nucleoside Scaffolds

Author(s) -

Meng Zhang,

Peichao Zhang,

Gudan Xu,

Wenting Zhou,

Yaojie Gao,

Rong Gong,

YouSheng Cai,

Hengjiang Cong,

Zixin Deng,

Neil P. J. Price,

Xiangzhao Mao,

Wenqing Chen

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01971-19

Subject(s) - nucleoside , biosynthesis , computational biology , biology , chemistry , biochemistry , gene

FOR-A and PRF-A areC -nucleoside antibiotics known for their unusual chemical structures and remarkable biological activities. Deciphering the enzymatic mechanism for the construction of aC -nucleoside scaffold during FOR-A/PRF-A biosynthesis will not only expand the biochemical repertoire for novel enzymatic reactions but also permit target-oriented genome mining of FOR-A/PRF-A-relatedC -nucleoside antibiotics. Moreover, the availability of FOR-A/PRF-A biosynthetic gene clusters will pave the way for the rational generation of designer FOR-A/PRF-A derivatives with enhanced/selective bioactivity via synthetic biology strategies.

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