Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo | Zendy

Xue Shen | Zendy; Xiaodi Niu | Zendy; Gen Li | Zendy; Xuming Deng | Zendy; Jianfeng Wang | Zendy

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Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo

Author(s) -

Xue Shen,

Xiaodi Niu,

Gen Li,

Xuming Deng,

Jianfeng Wang

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01804-18

Subject(s) - streptococcus suis , amentoflavone , microbiology and biotechnology , in vivo , in vitro , antibiotics , biology , pharmacology , virulence , biochemistry , gene

The widespread use of antibiotics in therapy and in the prevention ofStreptococcus suis infection in the swine industry raises concerns for the emergence of a resistant strain. The use of antivirulence agents has potential benefits, mainly because of the reduced selective pressure for the development of bacterial resistance. In this study, we found that amentoflavone is an effective agent againstS. suis serotype 2 (SS2) infection bothin vitro andin vivo . Our results demonstrated that amentoflavone is a promising anti-infective therapeutic forS. suis infections, due to its antivirulence and anti-inflammatory effects without antibacterial activity, with fewer side effects than conventional antibacterial agents.

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