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The widespread use of antibiotics in therapy and in the prevention ofStreptococcus suis infection in the swine industry raises concerns for the emergence of a resistant strain. The use of antivirulence agents has potential benefits, mainly because of the reduced selective pressure for the development of bacterial resistance. In this study, we found that amentoflavone is an effective agent againstS. suis serotype 2 (SS2) infection bothin vitro andin vivo . Our results demonstrated that amentoflavone is a promising anti-infective therapeutic forS. suis infections, due to its antivirulence and anti-inflammatory effects without antibacterial activity, with fewer side effects than conventional antibacterial agents.

Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo