Open AccessTranscriptome Analysis of Pseudomonas aeruginosa Biofilm Infection in an Ex Vivo Pig Model of the Cystic Fibrosis Lung
Author(s) -
Niamh E. Harrington,
Jenny Littler,
Freya Harrison
Publication year - 2022
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.01789-21
Subject(s) - pseudomonas aeruginosa , biology , transcriptome , biofilm , microbiology and biotechnology , sputum , ex vivo , in vivo , cystic fibrosis , lung infection , antibiotics , antibiotic resistance , gene expression , bacteria , gene , lung , genetics , pathology , medicine , tuberculosis , linguistics , philosophy
Pseudomonas aeruginosa lung infections that affect people with cystic fibrosis are resistant to most available antimicrobial treatments. The lack of a laboratory model that captures all key aspects of these infections hinders not only research progression but also clinical diagnostics.