Open AccessCatalase Expression in Azospirillum brasilense Sp7 Is Regulated by a Network Consisting of OxyR and Two RpoH Paralogs and Including an RpoE1→RpoH5 Regulatory Cascade
Author(s) -
Ashutosh Kumar,
Sudhir Singh,
Sushil K. Dwivedi,
Amit Srivastava,
Parul Pandey,
Santosh Kumar,
B. N. Singh,
Anil Kumar Tripathi
Publication year - 2018
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.01787-18
Subject(s) - azospirillum brasilense , sigma factor , biology , mutant , catalase , plasmid , regulation of gene expression , escherichia coli , microbiology and biotechnology , promoter , gene , gene expression , genetics , oxidative stress , biochemistry , bacteria , microbial inoculant
In silico analysis of theA. brasilense genome showed the presence of multiple paralogs of genes involved in oxidative stress response, which included 2 OxyR transcription regulators and 3 catalases. So far,Deinococcus radiodurans andVibrio cholerae are known to harbor two paralogs of OxyR, andSinorhizobium meliloti harbors three catalases. We do not yet know how the expression of multiple catalases is regulated in any bacterium. Here we show the role of multiple RpoH sigma factors and OxyR in regulating the expression of multiple catalases inA. brasilense Sp7. Our work gives a glimpse of systems biology ofA. brasilense used for responding to oxidative stress.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom