Enantioselective Dehydrochlorination of δ-Hexachlorocyclohexane and δ-Pentachlorocyclohexene by LinA1 and LinA2 from Sphingobium indicum B90A | Zendy

Birgit Geueke | Zendy; Milena E. Miska | Zendy; Thomas Poiger | Zendy; Daniel Rentsch | Zendy; Rup Lal | Zendy; Christof Holliger | Zendy; HansPeter E. Kohler | Zendy

Open Access

Enantioselective Dehydrochlorination of δ-Hexachlorocyclohexane and δ-Pentachlorocyclohexene by LinA1 and LinA2 from Sphingobium indicum B90A

Author(s) -

Birgit Geueke,

Milena E. Miska,

Thomas Poiger,

Daniel Rentsch,

Rup Lal,

Christof Holliger,

HansPeter E. Kohler

Publication year - 2013

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01770-13

Subject(s) - enantioselective synthesis , hexachlorocyclohexane , chemistry , biology , microbiology and biotechnology , biochemistry , catalysis , ecology , pesticide

δ-Hexachlorocyclohexane (δ-HCH), one of the prevalent isomers of technical HCH, was enantioselectively dehydrochlorinated by the dehydrochlorinases LinA1 and LinA2 from Sphingobium indicum B90A to the very same δ-pentachlorocyclohexene enantiomer. Racemic δ-pentachlorocyclohexene, however, was transformed with opposite enantioselectivities by the two enzymes. A transformation pathway based on an anti-1,2-elimination, followed by a syn-1,4-elimination and a subsequent syn-1,2-elimination is postulated.

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