Characterization of the ars Gene Cluster from Extremely Arsenic-Resistant Microbacterium sp. Strain A33 | Zendy

Asma Achour-Rokbani | Zendy; Audrey Cordi | Zendy; Pascal Poupin | Zendy; Pascale Bauda | Zendy; Patrick Billard | Zendy

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Characterization of the ars Gene Cluster from Extremely Arsenic-Resistant Microbacterium sp. Strain A33

Author(s) -

Asma Achour-Rokbani,

Audrey Cordi,

Pascal Poupin,

Pascale Bauda,

Patrick Billard

Publication year - 2009

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01738-09

Subject(s) - operon , gene cluster , gene , microbacterium , biology , mutant , genetics , escherichia coli , thioredoxin , plasmid , microbiology and biotechnology , 16s ribosomal rna

The arsenic resistance gene cluster of Microbacterium sp. A33 contains a novel pair of genes (arsTX) encoding a thioredoxin system that are cotranscribed with an unusual arsRC2 fusion gene, ACR3, and arsC1 in an operon divergent from arsC3. The whole ars gene cluster is required to complement an Escherichia coli ars mutant. ArsRC2 negatively regulates the expression of the pentacistronic operon. ArsC1 and ArsC3 are related to thioredoxin-dependent arsenate reductases; however, ArsC3 lacks the two distal catalytic cysteine residues of this class of enzymes.

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