Identification of Gold Nanoparticle-Resistant Mutants of Saccharomyces cerevisiae Suggests a Role for Respiratory Metabolism in Mediating Toxicity | Zendy

Mark R. Smith | Zendy; Matthew G. Boenzli | Zendy; Vihangi Hindagolla | Zendy; Jun Ding | Zendy; John Miller | Zendy; James E. Hutchison | Zendy; Jeffrey A. Greenwood | Zendy; Hagai Abeliovich | Zendy; Alan T. Bakalinsky | Zendy

Open Access

Identification of Gold Nanoparticle-Resistant Mutants of Saccharomyces cerevisiae Suggests a Role for Respiratory Metabolism in Mediating Toxicity

Author(s) -

Mark R. Smith,

Matthew G. Boenzli,

Vihangi Hindagolla,

Jun Ding,

John Miller,

James E. Hutchison,

Jeffrey A. Greenwood,

Hagai Abeliovich,

Alan T. Bakalinsky

Publication year - 2012

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01737-12

Subject(s) - saccharomyces cerevisiae , mutant , toxicity , biology , identification (biology) , metabolism , respiratory system , microbiology and biotechnology , computational biology , chemistry , biochemistry , yeast , gene , anatomy , botany , organic chemistry

Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.

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