mathFISH, a Web Tool That Uses Thermodynamics-Based Mathematical Models for In Silico Evaluation of Oligonucleotide Probes for Fluorescence In Situ Hybridization | Zendy

L. Şafak Yılmaz | Zendy; Shreyas Parnerkar | Zendy; Daniel R. Noguera | Zendy

Open Access

mathFISH, a Web Tool That Uses Thermodynamics-Based Mathematical Models for In Silico Evaluation of Oligonucleotide Probes for Fluorescence In Situ Hybridization

Author(s) -

L. Şafak Yılmaz,

Shreyas Parnerkar,

Daniel R. Noguera

Publication year - 2010

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01733-10

Subject(s) - in silico , in situ , oligonucleotide , fluorescence in situ hybridization , computational biology , fluorescence , oligomer restriction , computer science , biological system , chemistry , biology , physics , biochemistry , dna , organic chemistry , quantum mechanics , chromosome , gene

Mathematical models of RNA-targeted fluorescence in situ hybridization (FISH) for perfectly matched and mismatched probe/target pairs are organized and automated in web-based mathFISH (http://mathfish.cee.wisc.edu). Offering the users up-to-date knowledge of hybridization thermodynamics within a theoretical framework, mathFISH is expected to maximize the probability of success during oligonucleotide probe design.

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