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The Trx and Grx systems are deeply involved in bacterial responses to H2 O2 -induced oxidative stress. However, little is known about their roles in response to other ROS, such as organic peroxides (OPs). In this study, we usedS. oneidensis as a research model to investigate the interplay between Trx/Grx and OxyR/OhrR. We show that Trxs mediate the redox status of transcriptional OP-responding regulator OhrR. Although none of thetrx orgrx genes are directly controlled by OxyR or OhrR, expression oftrxA andtrxC is induced bytert -butyl hydroperoxide (t -BHP). We further show that thetrxA andtrxC genes respond to effects of glutathione (GSH) depletion rather than oxidation. These findings underscore the particular importance of Trx in the bacterial OP stress response.

Distinct Roles of Shewanella oneidensis Thioredoxin in Regulation of Cellular Responses to Hydrogen and Organic Peroxides