Transcriptional Regulator AcrR Increases Ethanol Tolerance through Regulation of Fatty Acid Synthesis in Lactobacillus plantarum | Zendy

Xiaopan Yang | Zendy; Kunling Teng | Zendy; Lili Li | Zendy; Rina Su | Zendy; Jie Zhang | Zendy; Guomin Ai | Zendy; Jin Zhong | Zendy

Open Access

Transcriptional Regulator AcrR Increases Ethanol Tolerance through Regulation of Fatty Acid Synthesis in Lactobacillus plantarum

Author(s) -

Xiaopan Yang,

Kunling Teng,

Lili Li,

Rina Su,

Jie Zhang,

Guomin Ai,

Jin Zhong

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01690-19

Subject(s) - lactobacillus plantarum , fatty acid , biochemistry , chemistry , biology , lactic acid , bacteria , genetics

Ethanol tolerance is essential forL. plantarum strains living in substances with more than 9% ethanol, such as wine and beer. The details regarding howL. plantarum adapts to ethanol are still lacking. This study demonstrates that AcrR regulates thede novo synthesis of fatty acids inL. plantarum adapting to toxic levels of ethanol. We also identified the ability of the TetR/AcrR family regulator to bind to the fatty acid biosynthesis gene promoter, PfabZ1 , inL. plantarum and defined the binding sites. This finding facilitates the induction of the adaptation ofL. plantarum strains to ethanol for food fermentation applications.

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