The Small Interfering RNA Pathway Is Not Essential for Wolbachia-Mediated Antiviral Protection in Drosophila melanogaster | Zendy

Lauren M. Hedges | Zendy; Ryuichi Yamada | Zendy; Scott L. O’Neill | Zendy; Karyn N. Johnson | Zendy

Open Access

The Small Interfering RNA Pathway Is Not Essential for Wolbachia-Mediated Antiviral Protection in Drosophila melanogaster

Author(s) -

Lauren M. Hedges,

Ryuichi Yamada,

Scott L. O’Neill,

Karyn N. Johnson

Publication year - 2012

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01650-12

Subject(s) - wolbachia , drosophila melanogaster , biology , rna interference , small interfering rna , rna , drosophila (subgenus) , rna silencing , virology , virus , microbiology and biotechnology , genetics , host (biology) , gene

Wolbachia pipientis delays RNA virus-induced mortality in Drosophila spp. We investigated whether Wolbachia-mediated protection was dependent on the small interfering RNA (siRNA) pathway, a key antiviral defense. Compared to Wolbachia-free flies, virus-induced mortality was delayed in Wolbachia-infected flies with loss-of-function of siRNA pathway components, indicating that Wolbachia-mediated protection functions in the absence of the canonical siRNA pathway.

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