Alcohol Acetyltransferase Eat1 Is Located in Yeast Mitochondria | Zendy

Aleksander J. Kruis | Zendy; Astrid E. Mars | Zendy; Servé W. M. Kengen | Zendy; Jan Willem Borst | Zendy; John van der Oost | Zendy; Ruud A. Weusthuis | Zendy

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Alcohol Acetyltransferase Eat1 Is Located in Yeast Mitochondria

Author(s) -

Aleksander J. Kruis,

Astrid E. Mars,

Servé W. M. Kengen,

Jan Willem Borst,

John van der Oost,

Ruud A. Weusthuis

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01640-18

Subject(s) - yeast , ethyl acetate , metabolic engineering , metabolic pathway , biochemistry , function (biology) , chemistry , acetyltransferase , biology , enzyme , microbiology and biotechnology , gene , acetylation

Ethyl acetate is a common bulk chemical that is currently produced from petrochemical sources. Several Eat1-containing yeast strains naturally produce large amounts of ethyl acetate and are potential cell factories for the production of bio-based ethyl acetate. Rational design of the underlying metabolic pathways may result in improved production strains, but it requires fundamental knowledge on the function of Eat1. A key feature is the location of Eat1 in the yeast cell. The precursors for ethyl acetate synthesis can be produced in multiple cellular compartments through different metabolic pathways. The location of Eat1 determines the relevance of each pathway, which will provide future targets for the metabolic engineering of bulk ethyl acetate production in yeast.

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