Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains | Zendy

Kelly Weedmark | Zendy; Dominic Lambert | Zendy; Philip Mabon | Zendy; Kristy Hayden | Zendy; Chantel Urfano | Zendy; Daniel Leclair | Zendy; Gary Van Domselaar | Zendy; John W. Austin | Zendy; Cindi R. Corbett | Zendy

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Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains

Author(s) -

Kelly Weedmark,

Dominic Lambert,

Philip Mabon,

Kristy Hayden,

Chantel Urfano,

Daniel Leclair,

Gary Van Domselaar,

John W. Austin,

Cindi R. Corbett

Publication year - 2014

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01573-14

Subject(s) - clostridium botulinum , bay , toxin , biology , neurotoxin , whole genome sequencing , botulism , clostridiaceae , genome , microbiology and biotechnology , genetics , gene , geography , biochemistry , archaeology

We sequenced 175Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin (bont ) coding sequences (CDSs). In addition tobont/E1 andbont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay.

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