Requirement of Signal Peptidase ComC and Thiol-Disulfide Oxidoreductase DsbA for Optimal Cell Surface Display of Pseudopilin ComGC in Staphylococcus aureus | Zendy

Magdalena M. van der KooiPol | Zendy; Ewoud Reilman | Zendy; Mark J. J. B. Sibbald | Zendy; Yanka K. VeenstraKyuchukova | Zendy; Thijs R. H. M. Kouwen | Zendy; Girbe Buist | Zendy; Jan Maarten van Dijl | Zendy

Open Access

Requirement of Signal Peptidase ComC and Thiol-Disulfide Oxidoreductase DsbA for Optimal Cell Surface Display of Pseudopilin ComGC in Staphylococcus aureus

Author(s) -

Magdalena M. van der KooiPol,

Ewoud Reilman,

Mark J. J. B. Sibbald,

Yanka K. VeenstraKyuchukova,

Thijs R. H. M. Kouwen,

Girbe Buist,

Jan Maarten van Dijl

Publication year - 2012

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01565-12

Subject(s) - dsba , staphylococcus aureus , biogenesis , oxidoreductase , microbiology and biotechnology , chemistry , thiol , cell , biochemistry , biology , bacteria , escherichia coli , enzyme , gene , genetics , periplasmic space

Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure.

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