Heterologous Production and Functional Characterization of Ageritin, a Novel Type of Ribotoxin Highly Expressed during Fruiting of the Edible Mushroom Agrocybe aegerita | Zendy

Annageldi Tayyrov | Zendy; Sophie Azevedo | Zendy; Robert Herzog | Zendy; Eva Vogt | Zendy; Simon Arzt | Zendy; Peter Lüthy | Zendy; Pie Müller | Zendy; Martin Rühl | Zendy; Florian Hennicke | Zendy; Markus Künzler | Zendy

Open Access

Heterologous Production and Functional Characterization of Ageritin, a Novel Type of Ribotoxin Highly Expressed during Fruiting of the Edible Mushroom Agrocybe aegerita

Author(s) -

Annageldi Tayyrov,

Sophie Azevedo,

Robert Herzog,

Eva Vogt,

Simon Arzt,

Peter Lüthy,

Pie Müller,

Martin Rühl,

Florian Hennicke,

Markus Künzler

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01549-19

Subject(s) - biology , ricin , biochemistry , ribosome , protein biosynthesis , heterologous , thiostrepton , heterologous expression , recombinant dna , gene , toxin , rna

Our results suggest a pronounced organismal specificity of a protein toxin with a very conserved intracellular molecular target. The molecular details of the toxin-target interaction will provide important insight into the mechanism of action of protein toxins and the ribosome. This insight might be exploited to develop novel bioinsecticides.

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